Linkage disequilibrium maps and association mapping.
نویسنده
چکیده
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 115 6 شماره
صفحات -
تاریخ انتشار 2005